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  1. Walters BJ, Mercaldo V, Gillon CJ, Yip M, Neve RL, Boyce FM, Frankland PW, Josselyn SA.  The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation. PDF
  2. Vetere G, Kenney JW, Tran LM, Xia F, Steadman PE, Parkinson J, Josselyn SA, Frankland PW. Chemogenetic Interrogation of a Brain-wide Fear Memory Network in Mice. PDF
  3. Josselyn SA, Köhler S, Frankland PW.  Heroes of the Engram. PDF
  4. Xia F, Yiu A, Stone SS, Oh S, Lozano AM, Josselyn SA, Frankland PW.  Entorhinal Cortical Deep-Brain Stimulation Rescues Memory Deficits In Both Young And Old Mice Genetically Engineered To Model Alzheimer’s Disease. PDF
  1. Berndt A, Lee SY, Wietek J, Ramakrishnan C, Steinberg EE, Rashid AJ, Kim H, Park S, Santoro A, Frankland PW, Iyer SM, Pak S, Ährlund-Richter S, Delp SL, Malenka RC, Josselyn SA, Carlén M, Hegemann P, Deisseroth K. Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity. Proc Natl Acad Sci U S A. PDF
  2. Epp JR, Silva Mera R, Köhler S, Josselyn SA, Frankland PW. Neurogenesis-mediated forgetting minimizes proactive interference. Nat Commun PDF
  3. Ehrlich DE, Josselyn SA. Plasticity-related genes in brain development and amygdala-dependent learning. Genes Brain Behav. PDF
  4. Walters BJ, Azam AB, Gillon CJ, Josselyn SA, Zovkic IB. Advanced In vivo Use of CRISPR/Cas9 and Anti-sense DNA Inhibition for Gene Manipulation in the Brain. Front Genet. PDF
  5. Park S, Kramer EE, Mercaldo V, Rashid AJ, Insel N, Frankland PW, Josselyn SA. Neuronal Allocation to a Hippocampal Engram. PDF
  6. Frankland PW, Josselyn SA. Neuroscience: In search of the memory molecule. PDF
  7. Morrison DJ, Rashid AJ, Yiu AP, Yan C, Frankland PW, Josselyn SA. Parvalbumin interneurons constrain the size of the lateral amygdala engram.PDF
  8. Rashid AJ, Yan C, Mercaldo V, Hsiang HL, Park S, Cole CJ, De Cristofaro A, Yu J, Ramakrishnan C, Lee SY, Deisseroth K, Frankland PW, Josselyn SA. Competition between engrams influences fear memory formation and recall.PDF
  9. Guskjolen A, Josselyn SA, Frankland PW. Age-dependent changes in spatial memory retention and flexibility in mice.PDF
  1. Frankland PW, Josselyn SA. Memory allocation. Neuropsychopharmacology PDF
  2. Epp JR, Niibori Y, Liz Hsiang HL, Mercaldo V, Deisseroth K, Josselyn SA, Frankland PW. Optimization of CLARITY for Clearing Whole-Brain and Other Intact Organs(1,2,3). eNeuro. PDF
  3. Ali AM, Reis JM, Xia Y, Rashid AJ, Mercaldo V, Walters BJ, Brechun KE, Borisenko V, Josselyn SA, Karanicolas J, Woolley GA. Optogenetic Inhibitor of the Transcription Factor CREB. Chem BiolPDF
  1. Yiu AP*, Mercaldo V*, Yan C, Richards B, Rashid AJ, Hsiang HL, Pressey J, Mahadevan V, Tran MM, Kushner SA, Woodin MA, Frankland PW & Josselyn SA. Neurons are recruited to a memory trace based on relative neuronal excitability immediately before training. Neuron pdf
  2. Arruda-Carvalho M, Restivo L, Guskjolen A, Epp J, Elgersma Y, Josselyn SA & Frankland PW (2014). Conditional deletion of α-CaMKII impairs integration of adult-generated granule cells into dentate gyrus circuits and hippocampus-dependent learning. Journal of Neuroscience, in press. PDF
  3. Akers KG*, Martinez-Canabal A*, Restivo L*, Yiu AP, De Cristofaro A, Hsiang HL, Wheeler AL, Guskjolen A, Niibori Y, Shoji H, Ohira K, Richards BA, Miyakawa T, Josselyn SA* & Frankland PW* (2014). Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science PDF
  4. Vieira PA, Lovelace JW, Corches A, Rashid AJ, Josselyn SA & Korzus E (2014). Prefrontal consolidation supports the attainment of fear memory accuracy. Learning & Memory pdf
  5. Richards BA, Xia F, Santoro A, Husse J, Woodin MA, Josselyn SA & Frankland PW (2014). Patterns across multiple memories are identified over time. Nature Neuroscience PDF
  6. Allemang-Grand R, Scholz J, Ellegood J, Cahill LS, Laliberté C, Fraser PE, Josselyn SA, Sled JG, Lerch JP. Altered brain development in early-onset murine model of Alzheimer’s disease. Neurobiology Aging PDF
  7. Hsiang HL, Epp JR, van den Oever MC, Yan C, Rashid AJ, Insel N, Ye L, Niibori Y, Deisseroth K, Frankland PW, Josselyn SAManipulating a “cocaine engram” in mice. Journal of Neuroscience pdf
  8. Arruda-Carvalho M, Akers KG, Guskjolen A, Sakaguchi M, Josselyn SA, Frankland PW. Posttraining ablation of adult-generated olfactory granule cells degrades odor-reward memories. Journal of Neuroscience PDF
  9. Frankland PW, Josselyn SA. Memory allocation. Neuropsychopharmacology PDF
  10. Josselyn S, Frankland PW. Another twist in the histone memory code. Cell ResPDF
  11. Alberini CM, Josselyn S, Tsai LH. Editorial. Neurobioly of Learning and Memory
  1. Kim J, Kwon JT, Kim HS, Josselyn SA & Han JH (2013). Memory recall and modifications by activating neurons with elevated CREB. Nature Neuroscience PDF
  2. Martinez-Canabal A, Akers KG, Josselyn SA & Frankland PW (2013). Age-dependent effects of hippocampal neurogenesis suppression on spatial learning. Hippocampus PDF
  3. Sargin D, Mercaldo V, Yiu AP, Higgs G, Han JH, Frankland PW & Josselyn SA (2013). CREB regulates spine density of lateral amygdala neurons: implications for memory allocationFrontiers in Behavioral Neuroscience PDF
  4. Cowansage KK, Bush DE, Josselyn SA, Klann E & Ledoux JE (2013). Basal variability in CREB phosphorylation predicts trait-like differences in amygdala-dependent memory. Proc Natl Acad Sci PDF
  5. Zhang L, Meng K, Jiang X, Liu C, Pao A, Belichenko PV, Kleschevnikov AM, Josselyn SA, Liang P, Ye P, Mobley WC & Yu YE (2013). Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. Hum Mol GenetPDF
  6. Frankland PW, Köhler S & Josselyn SA (2013). Hippocampal neurogenesis and forgetting.  Trends in Neuroscience. pdf
  7. Cancino C, Yiu AP, Fatt M, Dugani C, Flores E, Frankland PW, Josselyn SA, Miller F & Kaplan D (2013).  p63 regulates adult neural precursor and newly-born neuron survival to control hippocampal-dependent behavior. Journal of Neuroscience, 33, 12569-85. pdf.
  8. Sargin D, Botly LC, Higgs G, Marsolais A, Frankland PW, Egan SE, Josselyn SA (2013) Disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice. Neurobiology of Learning and Memory, 103, 39-49. pdf.
  9. Rashid AJ, Cole CJ, Josselyn SA. (2013) Emerging roles for MEF2 transcription factors in memory. Genes Brain and Behavior. pdf
  10. Martinez-Canabal A, Wheeler AL, Sarkis D, Lerch JP, Lu WY, Buckwalter MS, Wyss-Coray T, Josselyn SA, Frankland PW (2013). Chronic over-expression of TGFβ1 alters hippocampal structure and causes learning deficits. Hippocampus. pdf
  11. Wasserman DI, Wang HG, Rashid AJ, Josselyn SA, Yeomans JS (2013). Cholinergic control of morphine-induced locomotion in rostromedial tegmental nucleus versus ventral tegmental area sites. European Journal of Neuroscience. pdf
  12. Josselyn SA & Frankland PW (2013). mTORC2 actin on your memory. Nature Neuroscience, 16, 379-80. pdf
  13. Frankland PW & Josselyn SA (2013). Memory and the single molecule. Nature, 493, 312-3. pdf
  14. Sengar AS, Ellegood J, Yiu AP, Wang H, Wang W, Juneja SC, Lerch JP, Josselyn SA, Henkelman RM, Salter MW & Egan SE (2013). Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition. Journal of Neuroscience, 33, 4055-65. pdf
  15. Wheeler AL, Lerch JP, Chakravarty MM, Friedel M, Sled JG, Fletcher PJ, Josselyn SA, Frankland PW (2013). Adolescent cocaine exposure causes enduring macroscale changes in mouse brain structure. Journal of Neuroscience, 33, 1797-803. pdf
The Varsity (University of Toronto paper). Getting the Neurons Firing (interview)
  1. Cole CJ, Mercaldo V, Restivo L, Yiu AP, Sekeres MJ, Han JH, Vetere G, Ross PJ, Pekar T, Neve RL, Frankland PW & Josselyn SA (2012). MEF2 negatively regulates learning-induced structural plasticity and memory formation. Nature Neuroscience, 15, 1255-64. pdf
  2. Sekeres M, Mercaldo V, Richards B, Sargin D, Mahadevan V, Woodin M, Frankland PW & Josselyn SA. Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality. Journal of Neuroscience, 32, 17857-68. pdf
  3. Akers KG, Arruda-Carvalho M, Josselyn SA, & Frankland PW (2012). The ontogeny of fear memory formation, specificity and persistence in mice. Learning & Memory, 19, 598-604.
  4. Mansouri A, Min W, Cole CJ, Josselyn SA, Henderson JT, van Eede M, Henkelman RM, Ackerley C, Grunebaum E & Roifman CM (2012). Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice.  Neurobiology of Disease, 47, 201-209.
  5. Josselyn SA & Frankland PW (2012).  Infantile amnesia: A neurogenic hypothesis. Learning & Memory, 19, 423-33. pdf
  6. Martinez-Canabal A, Akers KG, Josselyn SA & Frankland, PW (2012). The effect of suppressing hippocampal neurogenesis on spatial learning changes across the lifespan. Hippocampus, 23, 66-74.
  7. Salih DAM, Rashid AJ, Colas D, de la Torre-Ubieta L, Zhu RP, Morgan AA, Santo EE,  Cole CJ,  Shamloo M, Butte AJ, Bonni A, Josselyn SA, Madison DV & Brunet A. FoxO6 regulates memory consolidation and synaptic function.  Genes and Development, 26, 2780-801. pdf
  8. Niibori Y, Yu T-S, Epp JR, Akers KG, Josselyn, SA & Frankland, PW (2012). Suppression of adult neurogenesis impairs population coding of similar contexts in the hippocampal CA3 region. Nature Communication, 4, 1253. pdf
  9. Gu Y, Arruda-Carvalho M, Wang J, Janoschka S, Josselyn SA, Frankland PW & Ge S. Reversible silencing of adult-born granule cells blocks hippocampal-dependent memory retrieval. Nature Neuroscience, 15, 1700-6. pdf
Discover Magazine write-up
  1. Yiu AP, Rashid A & Josselyn SA (2011). Increasing CREB in the dorsal hippocampus rescues the memory deficits in a mouse model of Alzheimer`s disease. Neuropsychopharmacology, 36, 2169-2186. pdf, see comment pdf
  2. Stone SSD, Teixeira CM, DeVito L, Zaslavsky K, Josselyn SA, Lozano AM & Frankland PW (2011). Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. Journal of Neuroscience, 31, 13469-13484. pdf
  3. Arruda-Carvalho M*, Sakaguchi M*, Akers KG, Josselyn SA & Frankland PW (2011). Adult-generated neurons form an essential component of hippocampal memory traces. Journal of Neuroscience, 31, 15113-15127. *equal contribution.
  4. Rashid A & Josselyn SA (2011).  The role of CREB in mammalian memory.  CNS and neurological disorders-Drug Targets.
  5. Suzuki A, Fukushima H, Mukawa T, Toyoda H, Wu LJ, Zhao MG, Xu H, Shang Y, Endoh K, Iwamoto T, Mamiya N, Okano E, Hasegawa S, Mercaldo V, Zhang Y,Maeda R, Ohta M, Josselyn SA, Zhuo M, & Kida S (2011). Up-regulation of CREB-mediated transcription enhances both short- and long-term memory, Journal of Neuroscience. 31, 8786-802.
  6. Lerch JP, Yiu AP, Martinez-Canabal A, Pekar T, Bohbot VD, Frankland PW, Henkelman RM, Josselyn SA & Sled JG. (2011). Maze training in mice induces MRI detectable brain shape changes specific to the type of learning. Neuroimage, 54, 2086-95. pdf
  7. Vetere G, Restivo L, Cole CJ, Ross PJ, Ammassari-Teule M, Josselyn SA, & Frankland PW (2011) Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory. Proc Natl Acad Sci U S A, 108, 8456-60.
Profile in BioTechniques pdf
  1. Josselyn SA (2010). Continuing the search for the engram.  J Psychiatry Neurosci, 35, 221-8. pdf
  2. Sekeres MJ, Neve RL, Frankland PW, & Josselyn SA (2010). Dorsal hippocampal CREB is both necessary and sufficient for spatial memory.  Learning & Memory, 21, 280-3. pdf
  3. Maei HR, Zaslavsky K, Wang AH, Yiu AP, Teixeira CM, Josselyn SA & Frankland PW (2009). Development and validation of a sensitive entropy-based measure for the water maze. Frontiers in Integrative Neuroscience, 3, 39-43.
  1. Han JH, Kushner SA, Yiu AP, Hsiang HL, Buch T, Waisman A, Bontempi B, Neve RL, Frankland PW & Josselyn SA (2009) Selective erasure of a fear memory.  Science, 323, 1492-1496. pdf
Press on this manuscript
  1. Wetzel MK, Naska S, Laliberte CL, Rymar VV, Fujitani M, Biernaskie JA, Cole CJ, Lerch JP, Spring S, Wang SH, Frankland PW, Henkelman RM, Josselyn SA, Sadikot AG, Miller FD & Kaplan DR. (2008) p73 haploinsufficiency causes age-related neurodegeneration and aberrant tau filament formation. Neuron, 59, 708-721 pdf
  2. Han JH, Yiu AP, Cole CA, Hsiang HL, Neve RL, & Josselyn SA (2008). Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fear.  Learning & Memory, 15, 443-453. pdf
  1. Han JH, Kushner SA, Yiu AP, Cole CA, Matynia A, Brown RA, Neve R, Guzowski JF, Silva AJ & Josselyn SA (2007). Neuronal competition and selection during memory formation.  Science, 316, 457-460. pdf
  1. Josselyn SA & Nguyen PV (2005).  CREB, synapses and memory disorders: past progress and future challenges. Curr Drug Targets CNS Neurological Disorders, 4, 481-497. pdf
  2. Josselyn SA (2005).  What’s right with my mouse model?  New insights into the molecular and cellular basis of cognition from mouse models of Rubinstein-Taybi Syndrome.  Learning and Memory, 12, 80-83. pdf
  3. Josselyn SA, Falls WA, Gewirtz JC, Pistell P & Davis M (2005). The nucleus accumbens is not critically involved in mediating the effects of a safety signal on Behavior. Neuropsychopharmacology, 30, 17-26. pdf
  4. Josselyn SA, Kida S, & Silva AJ (2004). Inducible Repression of CREB Function Disrupts Amygdala-Dependent Memory. Neurobiology of Learning and Memory, 82, 159-163. pdf
  5. Frankland PW Josselyn SA, Anagnostaras SG, Kogan JH, Takahashi E & Silva AJ (2004).  Consolidation of CS and US representations in associative fear conditioning.  Hippocampus, 14, 557-569. pdf
  6. Suzuki A, Josselyn SA, Frankland PW, Masushige S, Silva AJ & Kida S  (2004).  Memory reconsolidation and extinction have distinct temporal and biochemical signatures.  Journal of Neuroscience, 24, 4787-479.
  7. Bozon B, Kelly A, Josselyn SA, Silva AJ & Laroche S (2003).  MAPK, CREB and zif268 are all required for the consolidation of recognition memory.  Philosophical Transactions of the Royal Society London:  Biological Sciences, 358, 805-814.
  8. Silva AJ & Josselyn SA (2002). The molecules of forgetfulness.  Nature, 418, 929-930. pdf
  9. Josselyn SA*, Kida S*, Pena de Ortiz S, Kogan JH, Chevere I, Masushige S & Silva AJ (2002) CREB required for consolidation and reconsolidation of memory.  Nature Neuroscience, 5, 348-355.  (* both authors contributed equally to this work). pdf
  10. Josselyn SA, Shi CJ, Carlezon WA Jr, Neve R, Nestler EJ & Davis M (2001).  Long-term memory is facilitated by overexpression of CREB in the amygdala.  Journal of Neuroscience, 21, 2404-2412. pdf
  11. Anagnostaras SG, Josselyn SA, Frankland PW & Silva AJ  (2000). Computer-assisted behavioral assessment of Pavlovian fear conditioning. Learning & Memory, 7, 58-72.
  12. Josselyn SA, Miller R & Beninger RJ (1997).  Behavioral effects of clozapine and dopamine receptor subtypes.  Neuroscience and Biobehavioral Reviews, 21, 531-558.
  13. Josselyn SA, De Cristafaro A & Vaccarino FJ (1997).  Evidence for CCKA receptor involvement in the acquisition of conditioned activity produced by cocaine in rats.  Brain Research, 763, 93-102.
  14. Frankland PW, Josselyn SA, Vaccarino FJ, Bradwejn J & Yeomans JS (1997).  Activation of amygdala CCKB receptors potentiates the acoustic startle response in the rat.  Journal of Neuroscience, 17, 1838-1847.
  15. Josselyn SA & Vaccarino FJ (1997).  Acquisition of conditioned reward blocked by intra-accumbens infusion of PD-1450548, a CCKA receptor antagonist.  Pharmacology, Biochemistry and Behavior, 55, 439-444.
  16. Josselyn SA & Vaccarino FJ (1996).  Oppositional effects of CCKB and CCKA antagonists on the acquisition of conditioned locomotion.  Behavioral Pharmacology, 6, 505-512.
  17. Frankland PW, Josselyn SA, Bradwejn J, Vaccarino FJ & Yeomans JS (1996). Intracerebroventricular infusion of the CCKB receptor agonist pentagastrin potentiates acoustic startle.  Brain Research, 733, 129-132.
  18. Josselyn SA, Franco VP & Vaccarino FJ (1996).  PD-135158, a CCKB receptor antagonist microinjected into the nucleus accumbens and the expression of conditioned rewarded behavior.  Neuroscience Letters, 209, 85-88.
  19. Josselyn SA, Franco VP & Vaccarino FJ (1996).  Devazepide, a CCKA receptor antagonist, impairs the acquisition of conditioned reward and conditioned activity.  Psychopharmacology, 123, 131-143.
  20. Josselyn SA & Vaccarino FJ (1995).  Blockade of CCKB receptor interacts with intra-accumbens amphetamine to potentiate responding for conditioned rewards.  Peptides, 16, 959-964.
  21. Josselyn SA, Frankland PW, Petrisano S, Bush DEA, Yeomans JS & Vaccarino FJ (1995).  CCKB antagonist, L-365,260. Attenuates fear-potentiated startle.  Peptides, 16, 1313-1315.
  22. Josselyn SA & Beninger RJ (1993).  Neuropeptide Y:  Intra-accumbens injections produce a place preference that is blocked by cis-flupenthixol.  Pharmacology, Biochemistry and Behavior, 46, 543-552.
  23. Josselyn SA & Beninger RJ (1991).  Behavioral effects of intra-striatal caffeine mediated by adenosinergic modulation of dopamine.  Pharmacology, Biochemistry and Behavior, 39, 97-103.